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HST 522
Biomaterials: Tissue Interactions

Term: Fall

Course Director(s): Ioannis V. Yannas, Myron Spector
Time:
T/Th 2:30-4pm
Location:
3-370
Course Website:
None
Prerequisite:
Permission of instructor; Chemistry (GIR); Biology (GIR)
Restrictions:
None
MIT Units:
3-0-9 (G-Level Credit )
Harvard Units:
N/A
Principles of materials science and cell biology underlying the development and implementation of biomaterials for the fabrication of medical devices/implants, including artificial organs and matrices for tissue engineering and regenerative medicine. Employs a conceptual model, the "unit cell process for analysis of the mechanisms underlying wound healing and tissue remodeling following implantation of biomaterials/devices in various organs, including matrix synthesis, degradation, and contraction. Methodology of tissue and organ regeneration. Discusses methods for biomaterials surface characterization and analysis of protein adsorption on biomaterials. Design of implants and prostheses based on control of biomaterials-tissue interactions. Comparative analysis of intact, biodegradable, and bioreplaceable implants by reference to case studies. Criteria for restoration of physiological function for tissues and organs.