HST 527
Blood Vessels and Endothelial Phenotypes in Health and Disease

Overview of the endothelium as a model system for understanding biological complexity in health and disease. Emphasis placed on: mechanisms of endothelial cell heterogeneity, including genetic and microenvironmental determinants; the role of endothelial cell trafficking, hemostasis, barrier function, antigen presentation and vasomotor tone; and the role of endothelial cell dysfunction in disease, including tumors, sickle cell disease, pulmonary hypertension, veno-occlusive disease of the liver, thrombotic microangiopathies and xenotransplanation. Additional topics covered include novel proteomic and genomic strategies for mapping endothelial cell phenotypes, evolutionary (Darwinian) principles, and complexity theory. Knowledge of introductory biology or physiology, and biochemistry or molecular biology required.

Not Offered: Spring 2018