HST 535
Tissue Engineering and Regenerative Medicine

Term: Fall

Course Director(s): Myron Spector, Ioannis V. Yannas
T/Th 11am-12.30pm
MIT: 1-371
Course Website:
(Biology (GIR), Chemistry (GIR), and Physics I (GIR) or permission of instructor
MIT Units:
3-0-9 (G-Level Credit)
Harvard Units:
Leaders in the field present the principles and practice of tissue engineering (and regenerative medicine). Topics include the principles underlying strategies for employing select exogenous cells, biomaterial scaffolds, soluble regulators or their genes, and mechanical loading for the regeneration of tissues and organs in vitro and in vivo. Differentiated cell types and stem cells are compared and contrasted for this application, as are natural and synthetic scaffolds. Covers the rationale for employing selected growth factors and examines the methods for incorporating their genes into the scaffolds. Discusses the influence of environmental factors, including mechanical loading and culture conditions. Presents methods for fabricating tissue-engineered products and devices for implantation. Addresses the federal regulatory status of tissue-engineered products, as well as strategies for introducing such products into the clinic. Examples of procedures currently employed clinically are analyzed as case studies. All sessions are webcast to the world and archived for open access review at any time.