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		Engineering Functional Vessels In vivo: Use of Preadipocyte Patrick Au Harvard-MIT Division of Health Sciences and Technology Class 2001 Rakesh K. Jain, PhD Andrew Werk Cook Professor of Tumor Biology Department of Radiation Oncology Director, Edwin L. Steele Laboratory Massachusetts General Hospital
		Vascular endothelial cells (ECs) embedded in three dimensional (3-D) matrices are known to form vessel-like structures in a culture dish. Implantation of fat cell precursor (preadipocyte) subcutaneously in mice leads to formation of fat pad with matured vessels consist of arterioles, capillaries and venules Thus, we hypothesized that implantation of ECs and preadipocytes simultaneously in vivo may facilitate the formation of functional 3-D vasculature. We will evaluate the formation of functional networks in vivo and their physiological characteristics by intravital microscopy. The overall objective of the study is to evaluate the effectiveness of preadipocyte in the formation and stabilization of functional engineered vessels in vivo .
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(last modified 3/12/03)