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MEMP - Thesis Defense - Lina Avancini Colucci

Friday, April 13, 2018 -- 12:30 PM

Quantifying Fluid Overload with Portable Magnetic Resonance Sensors

The objective of this work was to translate MRI’s diagnostic capabilities to the patient bedside. Specifically, we studied the ability of portable magnetic resonance (MR) sensors to quantify fluid overload.

While MRI is used extensively in clinical medicine, it is still not used for routine diagnostics due to high cost, limited availability, and long acquisition times. Many of these impracticalities come from the hardware requirements associated with generating images. Images, however, are not necessary to harness some of MR’s diagnostic potential. We demonstrated a single-voxel MR sensor’s ability to obtain the same results as MRI images in both phantoms and humans.
 
We conducted a clinical study with hemodialysis patients and age-matched healthy controls at the Massachusetts General Hospital and quantified the T2 relaxation times of their legs at multiple time points with both a 1.5T clinical MRI scanner and our own 0.27T single-voxel MR sensor. Our results point towards a promising future of using cheaper, faster MR sensors for bedside diagnostics.

Thesis Supervisor:
Michael J. Cima, PhD
David H. Koch Professor of Engineering and Professor of Materials Science and Engineering, MIT

Thesis Committee Chair:
Elfar Adalsteinsson, PhD 
Professor of Health Sciences and Technology (HST) and of Electrical Engineering and Computer Science (EECS), Institute of Medical Engineering and Science (IMES), MIT
 
Thesis Readers:
Matthew Rosen, PhD
Assistant Professor in Radiology, HMS; Faculty, Athinoula A. Martinos Center for Biomedical Imaging
 
Kristin M. Corapi, MD, MMSc
Nephrologist, MGH
 
Date and Time: 
Friday, April 13, 2018 - 12:30pm to 2:30pm
Location: 
MIT 32-G449 (Stata Building, 4th Floor, Kiva Conference Room) 
Next to the R&D Commons