People
mehmet_toner@hms.harvard.edu
Mehmet Toner, PhD
HST Faculty, MEMP Alumnus
- Helen Andrus Benedict Professor of Surgery (Biomedical Engineering), and Health Sciences and Technology
Contact Information
- 617-724-5336
Degrees
- PhD in Medical Engineering, Massachusetts Institute of Technology, 1989
- MS in Mechanical Engineering, Massachusetts Institute of Technology, 1985
- BS in Mechanical Engineering, Istanbul Technical University, 1982
Selected Awards/Societies
- 1981 Ataturk, Founder of the Republic of Turkey Centenary Award, Turkey
- 1987-1989 Edwin Webster Fellowship, Harvard-MIT HST
- 1992-2006 Editorial Board, Journal of Cryobiology
- 1993-1998 National Institutes of Health FIRST Award
- 1994 Y.C. Fung Young Faculty Award in Bioengineering, A.S.M.E
- 1995-1998 The Whitaker Foundation Special Opportunity Award in Bioengineering
- 1997 John F./Virginia B. Taplin Faculty Fellow in Health Sciences and Technology
- 1997-2008 Associate Editor, Annual Reviews Biomedical Engineering
- 1998 Fellow, American Institute of Medical and Biological Engineering
- 1999-2003 Editorial Board, Cryo-Letters
- 2001-2003 President, Society for Cryobiology
- 2003- Associate Editor, Cell & Tissue Preservation, Cell Preservation Technology
- 2003- Scientific Advisory Board, Resource for Synthesis and Bulk Characterization of Polymer Biomaterials (RESBIO)
- 2004- Scientific Advisory Committee, Tissue Engineering Resource Center (TERC)
- 2005- Editorial Board, Nanomedicine
- 2006- Associate Editor, Journal of Cryobiology
- 2008- Editorial Board, Integrative Biology
- 2008- External Scientific Advisory Board, Institute of Engineering in Medicine, University of Minnesota
- 2008- External Advisory Board, Center for Biomedical Engineering, Brown University
- 2008 Fellow, American Society of Mechanical Engineers
- 2008 Popular Mechanics, Breakthrough Award
- 2009- External Advisory Board, Midwest Cancer Nanotechnology Training Center
- 2010 Team Award, American Association for Cancer Research (AACR)
Research Interests
Dr. Toner is motivated by multi-disciplinary problems at the interface of engineering and life sciences. He is highly regarded for his pioneering work in:
- Tissue Engineering: Bioartificial liver device, Skin tissue engineering, Cell-cell interactions in engineered complex tissues
- Cryobiology and Biostabilization: Long-term stabilization of mammalian cells and engineered tissues, Anhydrobiosis and metabolism, Thermodynamics and physical chemistry of phase changes
- Microfluidics and Micro/nanosystems Engineering: Living cell devices, Microfluidics in biology and medicine, Microfluidic blood processing, Integration of living cells and micro-engineered tissue units into micro-devices
- Global Health: Point of care monitoring for HIV/AIDS, Diagnosis and monitoring of tuberculosis, Manipulation of viral particles
- Cancer Metastasis: Circulating tumor cell biology, microchip for sorting of rare cells
Reference Publications
- Russo M, Bayley H, Toner M. Reversible permeabilization of plasma membranes with and engineered switchable pore. Nature Biotechnology 1997; 15: 278-282.
- Eroglu A, Russo M, Fowler A, Bayley H, Toner M. Intracellular trehalose improves the survival of cryopreserved mammalian cells. Nature Biotechnology 2000; 18: 163-168.
- Jeon NL, Baskaran H, Dertinger KW, Whitesides GM, Van De Water L, Toner M. Neutrophil chemotaxis in linear and complex gradients of IL-8 formed in a microfabricated device. Nature Biotechnology 2002: 20; 826-830.
- Aksan A, Irimia D, He XM, Toner M. Dessication kinetics of biopreservation solutions in microchannels. Journal of Applied Physics 2006; 99: 703-712.
- Pregibon DC, Toner M, Doyle PS. Multi-functional encoded particles for high-throughput biomolecule analysis. Science 2007; 315:1393-1396.
- Cheng X, Irimia D, Dixon M, Ziperstein JC, Demirci U, Zamir L, Tompkins RG, Toner M, Rodriguez W. A microchip approach for practical label-free CD4+ T cell counting of HIV-infected subjects in resource-poor settings. J AIDS 2007; 45: 257-261.
- DiCarlo D, Irimia D, Tompkins RG, Toner M. Continuous inertial focusing, ordering, and separation of particles in microchannels. Proceedings of the National Academy of Sciences USA 2007; 104: 18892-1889.
- Nagrath S, Sequist L, Bell DW, Irimia D, Ulkus L, Maheswaran S, Smith MR, Kwak EL, Ryan P, Balis UJ, Tompkins RG, Haber DA, Toner M. Microchip-based isolation of rare circulating epithelial cells in patients with metastatic cancer. Nature 2007; 450:1235-1239.
- Cheng X, Irimia D, Dixon M, Sekine K, Demirci U, Zamir L, Tompkins RG, Rodriguez W, Toner M. A microfluidic device for practical label-free CD4+ T cell counting of HIV infected subjects. Lab on a Chip 2007; 7: 170-178.
- King KR, Wang S, Jayaraman A, Yarmush ML, Toner M. Microfluidic flow-encoded switching for parallel control of dynamic cellular microenvironments. Lab on a Chip 2008; 8: 107-116.
- Maheswaran S, Sequist L, Nagrath S, Ulkus L, Brannigan B, Collura C, Inserra E, Diederichs S, Iafrate J, Digumarthy S, Muzikansky A, Irimia D, Settleman J, Tompkins R, Lynch T, Toner M, Haber D. Detection of mutations in EGFR in circulating lung-cancer cells. New England Journal of Medicine 2008; 359: 366-377.
- Russom A, Sethu P, Irimia D, Mindrinos MN, Calvano SE, Garcia I, Finnerty C, Tannahill C, Abouhamze A, Wilhelmy J, L?pez MC, Baker HV, Herndon DN, Lowry SF, Maier RV, Davis RW, Moldawer LL, Tompkins RG, Toner M; Inflammation and Host Response to Injury Large Scale Collaborative Research Program. Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients. Clinical Chemistry 2008; 54: 891-900.
- Menze MA, Boswell, Toner M, Hand SC. Occurrence of mitochondrial-targeted LEA gene in animals increases organelle resistance to water stress. Journal of Biological Chemistry 2009; 284:10714-10719.
- Edd JF, Humphry KJ, Irimia D, Weitz DA, Toner M. Nucleation and solidification in static arrays of monodisperse drops. Lab Chip. 2009; 9: 1859-65.
- Roach KL, King KR, Uygun K, Hand SC, Kohane IS, Yarmush ML, Toner M. High-throughput single cell arrays as a novel tool in biopreservation. Cryobiology. 2009; 58: 315-32.
- Irimia D, Mindrinos MN, Russom A, Xiao W, Wilhelmy J, Wang S, Heath JD, Kurn N, Tompkins RG, Davis RW, Toner M. Genome-wide transcriptome analysis of 150 cell samples. Integrative Biology 2009; 1: 99-107
- DiCarlo D, Edd JF, Humphry KJ, Stone HA, Toner M. Particle segregation and dynamics in confined flows. Physical Review Letters 2009; 102: 94503
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