Cryobiology and Biostabilization: Long-term stabilization of mammalian cells and engineered tissues, Anhydrobiosis and metabolism, Thermodynamics and physical chemistry of phase changes
Microfluidics and Micro/nanosystems Engineering: Living cell devices, Microfluidics in biology and medicine, Microfluidic blood processing, Integration of living cells and micro-engineered tissue units into micro-devices
Global Health: Point of care monitoring for HIV/AIDS, Diagnosis and monitoring of tuberculosis, Manipulation of viral particles
Cancer Metastasis: Circulating tumor cell biology, microchip for sorting of rare cells
Russo M, Bayley H, Toner M. Reversible permeabilization of plasma membranes with and engineered switchable pore. Nature Biotechnology 1997; 15: 278-282.
Eroglu A, Russo M, Fowler A, Bayley H, Toner M. Intracellular trehalose improves the survival of cryopreserved mammalian cells. Nature Biotechnology 2000; 18: 163-168.
Jeon NL, Baskaran H, Dertinger KW, Whitesides GM, Van De Water L, Toner M. Neutrophil chemotaxis in linear and complex gradients of IL-8 formed in a microfabricated device. Nature Biotechnology 2002: 20; 826-830.
Aksan A, Irimia D, He XM, Toner M. Dessication kinetics of biopreservation solutions in microchannels. Journal of Applied Physics 2006; 99: 703-712.
Pregibon DC, Toner M, Doyle PS. Multi-functional encoded particles for high-throughput biomolecule analysis. Science 2007; 315:1393-1396.
Cheng X, Irimia D, Dixon M, Ziperstein JC, Demirci U, Zamir L, Tompkins RG, Toner M, Rodriguez W. A microchip approach for practical label-free CD4+ T cell counting of HIV-infected subjects in resource-poor settings. J AIDS 2007; 45: 257-261.
DiCarlo D, Irimia D, Tompkins RG, Toner M. Continuous inertial focusing, ordering, and separation of particles in microchannels. Proceedings of the National Academy of Sciences USA 2007; 104: 18892-1889.
Nagrath S, Sequist L, Bell DW, Irimia D, Ulkus L, Maheswaran S, Smith MR, Kwak EL, Ryan P, Balis UJ, Tompkins RG, Haber DA, Toner M. Microchip-based isolation of rare circulating epithelial cells in patients with metastatic cancer. Nature 2007; 450:1235-1239.
Cheng X, Irimia D, Dixon M, Sekine K, Demirci U, Zamir L, Tompkins RG, Rodriguez W, Toner M. A microfluidic device for practical label-free CD4+ T cell counting of HIV infected subjects. Lab on a Chip 2007; 7: 170-178.
King KR, Wang S, Jayaraman A, Yarmush ML, Toner M. Microfluidic flow-encoded switching for parallel control of dynamic cellular microenvironments. Lab on a Chip 2008; 8: 107-116.
Maheswaran S, Sequist L, Nagrath S, Ulkus L, Brannigan B, Collura C, Inserra E, Diederichs S, Iafrate J, Digumarthy S, Muzikansky A, Irimia D, Settleman J, Tompkins R, Lynch T, Toner M, Haber D. Detection of mutations in EGFR in circulating lung-cancer cells. New England Journal of Medicine 2008; 359: 366-377.
Russom A, Sethu P, Irimia D, Mindrinos MN, Calvano SE, Garcia I, Finnerty C, Tannahill C, Abouhamze A, Wilhelmy J, L?pez MC, Baker HV, Herndon DN, Lowry SF, Maier RV, Davis RW, Moldawer LL, Tompkins RG, Toner M; Inflammation and Host Response to Injury Large Scale Collaborative Research Program. Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients. Clinical Chemistry 2008; 54: 891-900.
Menze MA, Boswell, Toner M, Hand SC. Occurrence of mitochondrial-targeted LEA gene in animals increases organelle resistance to water stress. Journal of Biological Chemistry 2009; 284:10714-10719.
Edd JF, Humphry KJ, Irimia D, Weitz DA, Toner M. Nucleation and solidification in static arrays of monodisperse drops. Lab Chip. 2009; 9: 1859-65.
Roach KL, King KR, Uygun K, Hand SC, Kohane IS, Yarmush ML, Toner M. High-throughput single cell arrays as a novel tool in biopreservation. Cryobiology. 2009; 58: 315-32.
Irimia D, Mindrinos MN, Russom A, Xiao W, Wilhelmy J, Wang S, Heath JD, Kurn N, Tompkins RG, Davis RW, Toner M. Genome-wide transcriptome analysis of 150 cell samples. Integrative Biology 2009; 1: 99-107
DiCarlo D, Edd JF, Humphry KJ, Stone HA, Toner M. Particle segregation and dynamics in confined flows. Physical Review Letters 2009; 102: 94503
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