People
jeffkarp@mit.edu
Jeffrey M. Karp, PhD
HST Faculty
- Associate Professor of Medicine, Harvard Medical School, Brigham & Women's Hospital
- Co-Director of Regenerative Therapeutics, Brigham and Women's Hospital
- Principal Faculty, Harvard Stem Cell Institute
Contact Information
- (617) 817-9174
Degrees
- PhD in Chemical and Biomedical Engineering, University of Toronto, 2004
- BEng in Chemical Engineering, McGill University, 1999
Selected Awards/Societies
- Champions in Healthcare, “Innovator” by Boston Business Journal (2011)
- Society For Biomaterials Young Investigator Award (2011)
- Coulter Translational Young Investigator Award (2010)
- HST McMahon Mentoring Award - Top mentor among all faculty who mentor HST students (2010)
- Gecko Tissue Adhesive Technology selected as one of seven "Next-Gen Bandages that Help Heal Wounds" by Popular Mechanics (2009)
- Gecko BioMedical Adhesive Technology selected as one of Popular Mechanic"s "Top 20 New Biotech Breakthroughs that Will Change Medicine" (2009)
- TR35 -- Recognized as one of the world's top innovators under age 35 (Technology Review) (2008)
- Outstanding Undergraduate Student Mentor Award at MIT (selected from all faculty at MIT) (2008)
Research Interests
I am dedicated to the development of next generation bioengineers to work at the forefront of regenerative medicine. I take the professional development of the personnel in my laboratory very seriously and do everything I can to ensure successful career paths.
My laboratory aims to create advanced biomaterials and devices for therapeutics through a highly multidisciplinary approach. Through working at the interface of material science, biology engineering, and medicine, our highly interactive and collaborative group engages outstanding scientists and clinicians at MIT, Harvard, Brigham and Women's Hospital and surrounding hospitals and institutions. A major focus of our group is the study and development of polymers and stem cells for addressing the biggest limitations in engineering replacement tissues and organs.
We have a moral obligation not only to solve problems that can benefit patients of the future but also to develop strategies that can rapidly be translated to the clinic to help patients today. Therefore, we attempt to examine our strategies within in vivo models as soon as possible. This facilitates the pertinent gain of knowledge for potential translational barriers that we may encounter so that we can begin problem solving the key hurdles as early as possible.
Reference Publications
- Ranganath SD, Levy O, Inamdar MS, Karp JM. Harnessing the Mesenchymal Stem Cell Secretome for the Treatment of Cardiovascular Disease. Cell Stem Cell. 2012 Mar 2;10(3):244-258.
- Sarkar D, Spencer JA, Phillips JA, Zhao W, Schafer S, Spelke DP, Mortensen, LJ, Ruiz JP, Vemula PK, Sridharan R, Kumar S, Karnik R, Lin CP, Karp JM. “Engineered Cell Homing”. Blood. 2011 Dec 15;118(25):e184-91.
- Zhao W, Loh W, Droujinine IA, Teo W, Kumar N, Schafer S, Cui CH, Zhang L, Sarkar D, Karnik R, Karp JM. “Mimicking the inflammatory cell adhesion cascade by nucleic acid aptamer programmed cell-cell interactions.” FASEB J. 2011 Sept;25(9):3045-56.
- Karp JM, Langer R. Materials Science: Dry Solution to a Sticky Problem. Nature. 2011 Aug 31;477(7362):42-3.
- Zhao W, Schafer S, Choi J, Yamanaka YJ, Lombardi ML, Bose S, Carlson AL, Phillips JA, Teo W, Droujinine IA, Cui CH, Jain RK, Lammerding J, Love JC, Lin CP, Sarkar D, Karnik R, Karp JM. “Cell surface aptamer sensors for real-time probing of cellular nanoenvironments.” Nature Nanotechnology. 2011 July 17;6(8):524-31.
- Vemula PK, Anderson RR, Karp JM. “Nanoparticles reduce nickel allergy by capturing metal ions.” Nature Nanotechnology. 2011 May;6(5):291-5.
- Basset E, Slocum A, Masiakos PT. Pryor, HI, Farokhzad O, Karp JM. Design of a Mechanical Clutch-based Needle Insertion Device. Proceedings of the National Academy of Sciences. 2009;106(14):5540-5.
- Karp JM, Teo G. Homing of mesenchymal stem cells: The devil is in the details. Cell Stem Cell. 2009 Mar 6;4(3):206-16.
- Mahdavi A, Ferreira L, Sundback C, Nichol JW, Chan EP, Carter JD, Bettinger C, Patanavanich S, Chignozha L, Ben-Joseph E, Galakatos A, Pryor H, Pomerantseva I, Masiakos P, Faquin W, Zumbuehl A, Hong S, Borenstein J, Vacanti J, Langer R, Karp JM. "A biodegradable and biocompatible Gecko-inspired tissue adhesive". Proceedings of the National Academy of Sciences (COVER FEATURE), 2008 Feb 19;105(7):2307-12.
Courses Taught
| HST 505 - JA 2013 - Laboratory in Molecular and Cellular Sciences | Laboratory in Molecular and Cellular Sciences |
| HST 977 - SP 2013 - Critical Reading and Technical Assessment of Biomedical Information | Critical Reading and Technical Assessment of Biomedical Information |
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