MIT E25-117 and Zoom
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Multifunctional soft robotic devices and cardiac benchtop models for improved therapy delivery and development
The goal of this thesis research is to improve patient-specific therapy by designing and developing (1) a suite of multifunctional implantable therapy delivery devices with dynamic drug delivery capabilities, and (2) a high-fidelity benchtop model that recreates cardiac anatomy and physiology. Part 1 involves the development of implantable, soft robotic devices that can dynamically respond to their local in vivo environment to trigger or modify therapy delivery according to patient-specific anatomy and patient-specific physiological signals. Part 2 involves the development of a dynamic benchtop model of the left atrium of the heart with interchangeable, clinical imaging derived left atrial appendages capable of replicating patient-specific hemodynamics and (patho)physiological motion. Taken together, this thesis research aims to create new therapeutic approaches that allow for patient-specific therapy delivery in response to each patient’s precise needs, and to support the development of future therapeutic approaches through the creation of new simulators that enable more personalized device testing and validation before deployment in a clinical setting.
Thesis Supervisor:
Ellen T. Roche, PhD
Latham Family Career Development Professor; Associate Professor of Mechanical Engineering and of the Institute for Medical Engineering & Science, MIT
Thesis Committee Chair:
Giovanni Traverso, MD, PhD
Karl Van Tassel (1925) Career Development Professor; Assistant Professor of Mechanical Engineering, MIT
Thesis Readers:
Xuanhe Zhao, PhD
George N. Hatsopoulos (1949) Faculty Fellow; Professor of Mechanical Engineering and Civil and Environmental Engineering, MI
Aaron Aguirre, MD, PhD
Assistant Professor of Medicine, Cardiology, Massachusetts General Hospital and Harvard Medical School
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Keegan Mendez is inviting you to a scheduled Zoom meeting.
Topic: Keegan Mendez Thesis Defense
Time: Wednesday, May 3, 2023 11:00 AM Eastern Time (US and Canada)
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