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Volumetric optical imaging of tissue microstructure for grading of dysplasia in vivo
Optical imaging offers unique advantages in medical diagnostics. In particular, high resolution, fast imaging speed, and relatively strong depth penetration make optical coherence tomography (OCT) an attractive modality for non-perturbatively investigating structural changes in tissue that accompany disease progression on the microscale. Although clinical interpretation of OCT images is generally qualitative, the scattered light intensity signal that produces these images may be analyzed further to calculate sub-resolution sample properties, accessing additional functional information in tissue. Developing meaningful ways to compute and interpret these properties could enable earlier detection of structural disease-associated tissue changes, such as increases in sizes and densities of epithelial nuclei with the progression of esophageal dysplasia. In this thesis research, we investigate the application of novel signal processing methods and custom OCT hardware to uncover biomarkers of dysplasia based on these pathological changes in cell nuclei. Further, we apply our platform to evaluate patients during upper gastrointestinal endoscopy using a custom imaging device designed for enhanced sensitivity to these dysplastic changes, potentiating an improved screening paradigm towards earlier detection of esophageal cancer.
Thesis Supervisors:
Brett E. Bouma, PhD
Professor of Dermatology and Health Sciences and Technology, HMS
Néstor Uribe-Patarroyo, PhD
Assistant Professor of Dermatology, HMS
Thesis Committee Chair:
Elfar Adalsteinsson, PhD
Eaton-Peabody Professor, Electrical Engineering and Computer Science and Institute for Medical Engineering and Computer Science, MIT
Thesis Reader:
Aaron Aguirre, MD, PhD
Assistant Professor of Medicine, HMS
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Taylor Marie Cannon is inviting you to a scheduled Zoom meeting.
Topic: Taylor Cannon Thesis Defense
Time: Thursday, April 20, 2023 03:00 PM Eastern Time (US and Canada)
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